This position will be responsible for providing analytical chemistry and formulation support for small molecule, oligonucleotide and protein-based drug candidates to advance Dynavax’s immuno-oncology research programs in the field of Toll Receptor agonism.
· Conduct laboratory-based analytical chemistry and formulation research activities with small molecule, oligonucleotide and/or protein-based drug candidates, including; compound formulation, sample management, analytical method development / optimization, and bioconjugation chemistry.
· Contribute to the design and execution of in vitro and in vivo PK/DM experiments.
· Execute experimental protocols and collect / record results, must be able to effectively troubleshoot experiment procedures.
· Analyze experimental data, prepare and submit technical reports, and present results at project team and departmental meetings.
· Coordinate day-to-day laboratory activities to ensure reagents are available and maintenance of equipment.
· Document all scientific work in lab notebooks, follow established Dynavax standard operating procedures on data documentation and notebooks, and adhere to Dynavax Quality Systems standards.
· Support the organization in maintaining a work environment focused on quality and that fosters learning, open communication, collaboration, integration, and team work.
· Other duties as assigned.
· BS or MS in life science, either in chemistry, biochemistry and/or other related discipline.
· Required experience will vary depending on level: RA II level with BS and 3+ years relevant experience; RA III level with BS and 5+ years, or an MS with 2+ years’ of relevant experience.
· Relevant laboratory experience includes:
- small molecule / oligonucleotide / protein compound formulation and management.
- purification / analysis of small molecules, oligonucleotides, and / or proteins by high or low pressure LC methods (RP, SEC, HIC, etc.).
- other analytical methods, including SDS-PAGE, UV spectroscopy, DLS, zeta-potential, endotoxin determination, etc.
- familiarity with bioconjugation chemistries / methodology.
- experience with harvesting tissues from laboratory mice and processing for bioanalysis.
· Proficiency with Word, Excel, Powerpoint, Prism, and ChemDraw software.
· Must be capable of working independently, have careful attention to experimental details, and possess excellent record-keeping and strong organizational skills.
· Excellent written and verbal communication skills.
Additional knowledge and skills desired, but not required:
· Mass spectroscopy and its application to the field of biotechnology.
· Familiarity with fundamental concepts in immuno-oncology.