Dynavax Technologies

  • Research Associate II/III

    Job Location US-CA-Berkeley
    Posted Date 2 months ago(2/13/2018 5:27 PM)
    ID
    18-021N
    Category
    R&D
  • Overview

     This position will be responsible for providing analytical chemistry and formulation support for small molecule, oligonucleotide and protein-based drug candidates to  advance Dynavax’s immuno-oncology research programs in the field of Toll Receptor agonism.

     

     

     

    Responsibilities

    • ·         Conduct laboratory-based analytical chemistry and formulation research activities with small molecule, oligonucleotide and/or protein-based drug candidates, including; compound formulation, sample management, analytical method development / optimization, and bioconjugation chemistry.

       

      ·         Contribute to the design and execution of in vitro and in vivo PK/DM experiments.

       

      ·         Execute experimental protocols and collect / record results, must be able to effectively troubleshoot experiment procedures.

       

      ·         Analyze experimental data, prepare and submit technical reports, and present results at project team and departmental meetings.

       

      ·         Coordinate day-to-day laboratory activities to ensure reagents are available and maintenance of equipment.

       

      ·         Document all scientific work in lab notebooks, follow established Dynavax standard operating procedures on data documentation and notebooks, and adhere to Dynavax Quality Systems standards.

       

      ·         Support the organization in maintaining a work environment focused on quality and that fosters learning, open communication, collaboration, integration, and team work.

       

      ·         Other duties as assigned.

       

     

    Qualifications

    ·         BS or MS in life science, either in chemistry, biochemistry and/or other related discipline.

     

    ·         Required experience will vary depending on level:  RA II level with BS and 3+ years relevant experience; RA III level with BS and 5+ years, or an MS with 2+ years’ of relevant experience.

     

    ·         Relevant laboratory experience includes:

    -   small molecule / oligonucleotide / protein compound formulation and management.

    -   purification / analysis of small molecules, oligonucleotides, and / or proteins by high or low pressure LC methods (RP, SEC, HIC, etc.).

    -   other analytical methods, including SDS-PAGE, UV spectroscopy, DLS, zeta-potential, endotoxin determination, etc.

    -   familiarity with bioconjugation chemistries / methodology.

    -   experience with harvesting tissues from laboratory mice and processing for bioanalysis.

     

    ·         Proficiency with Word, Excel, Powerpoint, Prism, and ChemDraw software.

     

    ·         Must be capable of working independently, have careful attention to experimental details, and possess excellent record-keeping and strong organizational skills. 

     

    ·         Excellent written and verbal communication skills.

     

    Additional knowledge and skills desired, but not required:

    ·         Mass spectroscopy and its application to the field of biotechnology.

     

    ·         Familiarity with fundamental concepts in immuno-oncology.

     

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